A Case study regarding Autoimmune Encephalopathy/PANS and Ozone Therapy

Case Study of Major Autohemotherapy and improvement of Autoimmune Encephalopathy symptoms with a 17-year-old male.

I can continue to post scientific blogs about various treatment regimens, but I find the proof is in the pudding so to speak by presenting case studies of rather difficult cases.

This first case is of a 17-year-old male who came to me a year ago with extensive history of language delays and cognitive dysfunction after receiving his 12-month-old vaccinations. We refer to this a regressive autoimmune encephalopathy, although not recognized widely by the medical community, it is considered a vaccine injury.

The mother reported throughout his childhood he would have a flare of anxiety, regressive behaviors regarding cognition with each consecutive vaccine. Eventually he would return to baseline, but the symptoms continued to build and eventually plague his everyday life. By the age of 8 this child had significant OCD, tics followed by age 9 with suicidal ideations and intrusive thoughts. He was evaluated by his PCP and Psych numerous times and trialed on medications.

By 2016 he was found to have elevated strep antibodies as well as mycoplasma titers. He was trialed on a short course of antibiotics and felt “really great” for a period. He seemed to stabilize with Ibuprofen and Azithromycin. In August of 2018 the patient received his meningitis vaccine. Within two weeks of that vaccine the patient had a complete meltdown. Remember, he was finally stable with ongoing medications. His anxiety was debilitating, he refused to go to school. The intrusive thoughts returned along with the significant OCD.  He would express to his mother that his “brain wasn’t right”. By November of 2018 he and his family found their way to my office.

After a comprehensive evaluation and a battery of testing, I began to focus efforts upon GI support and detox. He was given course of antifungals and started upon a gluten-free, dairy-free, sugar-free diet. He noticed significant improvements within a month’s time. Labs showed overgrowth of Candida, Enterobacter and Klebsiella in pathogenic levels. I started an antibiotic and herbal regimen to address the bacteria and rebalance his gut.

I noted over the course of the following months improvement with overall behaviors. His moods were stable, mom noted fewer mood swings and no aggressive meltdowns. He seemed to be on the mend.

After several months of treatment, we retested his stool for bacteria overgrowth as well as additional monitoring labs and infectious panels. The patient was cruising along until we held the medications for a period to retest the stool as recommended. Within three days of coming off the regimen the patient noted significant tics, OCD, anxiety and intrusive thoughts. The suicidal ideations returned.

Once the regimen was restarted, the patient’s symptoms stabilized. Understanding continuing antibiotic regimens was not a life-long solution, I discussed the possibility of trialing MAH (major autohemotherapy). We discussed the risks and benefits extensively with the family who were then willing to give it a try.

If you’ve read any of my previous posts about ozone therapy, you’ll know the benefit of mitochondrial repair and NAD/NADH rebalancing.

We started his first MAH treatment in May of 2019. I began a low to moderate dose, around 30 gammas. The patient tolerated the treatment without side effects. Mom reported that the treatment was a game changer at their follow up appointment a month later. The patient reported not only stabilization of mood, but concentration was significantly better along with energy and sleep patterns.

MAH was continued and with each consecutive treatment, positive gains were noted. I began adding additional glutathione infusions and vitamin C following the MAH. We were able to wean down Lexapro and completely discontinue Strattera that the patient had maintained prior to his first visit with me. This occurred after about the 8th MAH treatment.

The patient is now back in school and moving forward with social interactions as expected from a teenager.

We understand the mechanisms of autoimmune encephalopathy and the varying presentation and causative agents of this condition. Clearly the focus is upon removing the trigger if possible and continue the healing process. Understanding the mechanisms of MAH therapy just made sense as a next step. If we could not only heal his underlying imbalances and infections but rebalance his NAD/NADH ratio by using the 03 via MAH as a catalyst.

By far this is the biggest success with MAH therapy so far with my patients. I continue to prescribe this therapy and note a trend of cognitive improvements with many of my Chronic Lyme and tick-borne coinfection, PANS/PANDAS and Autoimmune Encephalopathy patients

somer delsignore